Software Engineer
Cambridge, MA

Job Description

Company Overview

At CRISPR Therapeutics, we are focused on developing transformative gene-based medicines for serious human diseases.

We are rapidly translating our specific, efficient and versatile CRISPR/Cas9 gene-editing platform into therapies to treat hemoglobinopathies, cancer, diabetes and other diseases

Our multi-disciplinary team of world-class researchers and drug developers works every day to translate our CRISPR/Cas9 technology into breakthrough human therapeutics. Our lead program targeting the blood diseases β-thalassemia and sickle cell disease has entered clinical testing, and our immuno-oncology programs, focused on CRISPR/Cas9-edited allogeneic CAR-T cell therapies, have the potential to deliver a new generation of cancer therapies to patients.

Job Summary

We are seeking a talented Software Engineer to tackle challenging bioinformatics and computational biology problems and work collaboratively with research groups to build and maintain the tools and pipelines required to support the development of new, transformative CRISPR/Cas9-based gene editing therapies.

Responsibilities

* Develop frontend, backend, web security and infrastructure for a variety of cutting-edge bioinformatics and next generation sequencing (NGS) tools
* Integrate with an energetic, fast-paced team to quickly deploy computational tools into internal web interfaces that serve a broad user base
* Convert research prototype scripts into robust scientific software optimized for performance, scalability, and adherence to best coding practice
* Run analysis pipelines on data generated from novel CRISPR/Cas9 assays, and work closely with preclinical teams to deliver insights and recommendations to decision makers
* Translate computational tools into web interfaces for a broad user base and organize results into stable databases for downstream meta-analysis
* Creatively troubleshoot issues, implement test cases, and fix bugs
* Give accurate time estimates based on verbal and written specifications

Minimum Qualifications

* Degree (B.S. with 2+ years of web/software development experience or graduate degree) in quantitative or basic science (computational biology, bioinformatics, computer science, molecular biology, chemistry, physics, or mathematics preferred)
* Ability to implement, debug, and maintain computational tools in common programming languages (e.g. JavaScript, Python, R, C/C++)
* Experience with web development frameworks (e.g. Django, Angular.js) and relational databases (e.g. MySQL)
* Proficiency with handling large-scale genomic data and web app architecture in a Linux and/or cloud environment (e.g. AWS)
* Experience with version control software (e.g. Git)
* Ability to work independently and successfully in a matrix environment, prioritize and manage multiple tasks simultaneously, integrate cross-functional issues and balance competing priorities effectively
* Good communication skills including research report and paper writing, code documentation, and oral presentation

Preferred Qualifications

* Experience in processing NGS data through bioinformatics pipelines and usage of common bioinformatics tools (e.g. BWA, BEDtools, GATK, IGV)
* Experience with DevOps tools (e.g. Docker, Jenkins, Puppet)
* Experience writing automated functional and unit test scripts
* Background in team-based coding, repository and branch management
* Familiarity with molecular biology techniques, gene editing, and/or CRISPR/Cas9 biology
* A high degree of energy, accuracy and attention to detail, and a passion for creating transformative gene-based medicines for patients with serious diseases
* Familiarity with LIMS and other sample and data tracking systems

CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

To view our Privacy Statement, please click the following link: http://www.crisprtx.com/about-us/privacy-policy