We have developed a patient-engagement software platform to capture and analyze patient reported outcome (PRO) data to better measure what works and what doesn't work in the real world. Our unique rules-based approach completely automates all patient interactions via the web and seamlessly ties-in physical healthcare personnel activity to execute PRO studies in less time and with greater return on investment. Observational studies typically suffer from poor patient compliance so our platform includes novel incentives that have boosted compliance to 3X what's available today. Using our EMR integration framework with validity analytics, bias inherent in current PRO methods can be made more transparent and minimized. Most of the information we capture will not exist in the clinical record, EMR, clinical trial literature, or claims data but we can tie those sources of information into one common real time view of real world patient experience. Our hope is that our platform will help improve healthcare effectiveness for patients with chronic disease. For industry, our system can deliver PRO measures for comparative effectiveness (CER), adherence, treatment satisfaction, quality of life, work productivity, and healthcare utilization to improve market access (reimbursement), prescriber demand, new indications, labeling, pharmacovigilance/safety, and quality tracking.